Light
and sound, by augmenting existing therapies or eradicating infections or
conditions outright, may also prove critical in defeating Alzheimer’s,
Parkinson’s, AIDS and every other infectious disease on Earth besides AIDS. These
effects may not exactly be a #CancerMoonshot, but given the opportunity to
bring them up – and potentially to wipe out over half the major diseases on
Earth – we might as well cover all bases. The methods would not be exactly the
same in each case, but there is sufficient overlap between them to warrant
further consideration, especially given the advantages noted in our
initial
#CancerMoonshot.
To
begin, there are frequencies of blue and red light which can kill bacteria,
extremely brief pulses of laser light can destroy viruses, ultrasound can be
tuned to destroy specific pathogens whether viral or bacterial, infrared light
and ultrasound can destroy protein tangles (and ultrasound can ease open the
blood-brain barrier to help sweep them away), near-infrared light can already
help treat Parkinson’s and visible and infrared light (not to mention DCA,
quercetin and PQQ) can reactivate mitochondria. How does all of this help us?
Because,
as with cancer, we may be able to combine these non-traditional and mostly
non-toxic interventions in ways that enhance their potency and compensate for
each other’s limitations. We will get to those enhancements shortly. But first,
let’s review the above techniques.
So, red
and
blue LEDs
have both been used to kill bacteria. For example,
this
study on the impact of blue light on bacterial infection or
this one on red light
destroying bacteria through photodynamic action.
“In a proof-of-concept study, led
by Dr. Michael R. Hamblin of Massachusetts General Hospital and Harvard Medical
School, an array of blue LEDs was used to treat infected burns on lab mice.
More specifically, the blue light was used to selectively eradicate
potentially-lethal Pseudomonas aeruginosa bacteria in the animals’ skin
and soft tissues.
“The results of the study were
promising. All of the light-treated mice survived, while 82 percent of the
untreated control group died. Additionally, unlike bacteria-killing ultraviolet
light, the blue light wasn’t harmful to the animals’ own cells.”
This technology is probably the
least dramatic option available to us, but is an important place to start. As
noted
previously, not only can these lights shine with some limited penetration
through human skin, every endoscopic probe contains a fiber-optic cable,
allowing access into the body’s depths though the respiratory, digestive and
circulatory systems.
Further, if red and blue LED lights
can be used to kill bacteria, why not use genetic engineering to create blood cells
with similar properties for temporary transfusion into the body (using optogenetics as an optional trigger)? Modifying
organisms to give them bioluminescence is, for better or worse, one of the most
common demonstrations of genetic modification and red blood cells do not
reproduce themselves. Such a transfusion could be run through the body
temporarily until replaced by a second transfusion or simply left in place
until the cells were replaced naturally. Either way, modified cells would
represent a relatively non-invasive way to wipe out a rampant bacterial
infection.
But
while eliminating bacteria is useful, it is only the beginning.
Further,
certain frequencies of light have been observed to break up the protein tangles
associated with Alzheimer’s. To the extent that countering this symptom helps
in the disease’s overall treatment, it is worth noting. Indeed, any symptoms
which can be countered in a safe, non-invasive way may be worth eliminating,
particularly if these interventions prove effective in slowing the pace of the
condition.
Johns
Hopkins came up with a means of killing viruses via laser, albeit one which
is of greater value, at present, for purging blood and other fluids removed
from the body.
“A study by Kong-Thon Tsen of
Arizona State University along with researchers at Johns Hopkins University
shows how strong blasts of visible light from a low-power laser can kill
viruses.”
“The researchers aimed a low-power laser with a pulse lasting 100
femtoseconds (10-13 second) into glass tubes containing saline-diluted viruses
that infect bacteria, also known as bacteriophages. The amount of
infectious virus within each cube plummeted 100- to 1000-fold after the laser
treatment.”
Granted,
this particular technology would be of greater use at present in purging a
patient’s blood, lymph and/or other bodily fluids, particularly if it were
impractical to simply transfuse uninfected fluids to replace them. However, as
micro-technology improves, including a temporary or permanent stint in a large
blood vessel to deliver these pulses and steadily purge the circulatory system
of viruses might have its own advantages. Unfortunately, even given a
non-chemical form of high-density power storage, there limits to how much
concentrated energy we will want to implant in the sensitive tissues of a human
body, and the only means of point-to-point energy transmission likely to emerge
in the near future is not available for public consumption for unrelated safety
issues. Still, as a means of augmenting other antiviral procedures, this
technology is worth noting.
Which
brings us to a more promising method of attacking viral invaders throughout the
body,
ultrasound. To
sum up:
“Healthy cells and tissue have a
natural frequency within which they resonate. Maladies such as viruses,
bacteria, parasites, other infectious agents, and cancerous cells/tissue
generally have different natural resonating frequency ranges compared to
healthy cells and tissue. If a carefully selected level of ultrasound energy
with a carefully selected frequency is delivered to a subject with a malady,
the ultrasound energy has the capability of destroying viruses, bacteria,
parasites, other infectious agents, and cancerous cells/tissue at their
respective resonating frequencies. An advantage is that due to the differences
in the natural resonance ranges, one frequency that disrupts or destroys
viruses, bacteria, parasites, other infectious agents, and cancerous
cells/tissue can leave healthy cells and tissue unharmed.”
Determining
the ideal resonant frequency for destroying a particular target – viral,
bacterial, parasitic, etc – should be a simple matter of testing, and those
frequencies can be recorded to create a library for medical practitioners. This
testing should ultimately be automated to speed the analysis of every major
viral and bacterial infection, though of course still supported with human
oversight. Should a particular species change rapidly over time, such as a
typical flu virus, simply extract a sample of the targeted pathogen as
necessary and test destructive frequencies on it again. Augmented by other
resources such as existing medications, light-based therapies and so forth, it
should be possible to decimate any normal infection in short order, and potentially
to defeat even extraordinarily resilient viruses such as AIDS.
Which
brings us to
another
application of ultrasound, breaking up beta-amyloid tangles and removing
them from the brain. Granted, the degree to which beta-amyloids and tau
proteins are the primary or sole culprit in the deterioration due to
Alzheimer’s is an open question, but obviously the team investigating this
method enjoyed positive results from it.
“Publishing in Science
Translational Medicine, the team describes the technique as using a particular
type of ultrasound called a focused therapeutic ultrasound, which
non-invasively beams sound waves into the brain tissue. By oscillating
super-fast, these sound waves are able to gently open up the blood-brain
barrier, which is a layer that protects the brain against bacteria, and
stimulate the brain’s microglial cells to activate. Microglila cells are
basically waste-removal cells, so they’re able to clear out the toxic
beta-amyloid clumps that are responsible for the worst symptoms of Alzheimer’s.
“The team reports fully restoring
the memory function of 75 percent of the mice they tested it on, with zero
damage to the surrounding brain tissue. They found that the treated mice
displayed improved performance in three memory tasks - a maze, a test to get
them to recognise new objects, and one to get them to remember the places they
should avoid.”
Clearly,
if damage has already been done, then eliminating the proximate cause may not
lead to ultimate repair of that injury, though it can help prevent matters from
getting worse. Still, we want to examine multiple methods of treatment for both
halting the decline and reversing existing loss of function, memory, etc.
With
Parkinson’s, there is a question of whether the accumulated Lewy bodies found
in deteriorating parts of the brain are a cause of the damage or protective. In
the former case, however, the ability to break down and remove these structures
may prove useful, using the same methods described above for Alzheimer’s.
However, there is
another
proposal suggesting that red and infrared light - especially near-infrared
light - could have neuroprotective effects on those suffering from Parkinson’s
and Alzheimer’s by restoring mitochondrial functions in ailing brain cells.
The linked article is worth reading
in its entirety. But to include some excerpts: “Previous studies have used NIr to treat tissue stressed by hypoxia, toxic
insult, genetic mutation and mitochondrial dysfunction with much success. Here
we propose NIr therapy as a neuroprotective or disease-modifying treatment for
Alzheimer's and Parkinson's patients.”
“In the context of Alzheimer's
and Parkinson's disease, although they have distinct initiating causes, both
diseases converge on common pathways of inflammation and oxidative stress,
mitochondrial dysfunction and neuronal death, indicating that NIr may be
beneficial to both through the same protective mechanisms.”
“To the best of our knowledge,
there have been no major publications—at least in peer-reviewed journals—on the
efficacy of NIr in Alzheimer's patients. There are some web pages referring to
either an Alzheimer extracranial “helmet,” housing many LEDs of wavelengths
ranging from 660 to 1070 nm (e.g., http://www.emersonww.com/InfraredHelmet.htm; http://www.science20.com/news_releases/can_this_infra_red_helmet_cure_alzheimers_in_10_minutes_a_day; http://www.instructables.com/id/LED-helmet-for-dementia-alzheimers-parkinsons), or an intranasal device delivering NIr
to the brain (http://www.mediclights.com/wp-content/uploads/2013/11/Alzheimer-with-intranasal-light-08-22-13-1.pdf). However, there are no reports, either
published, or in progress, of clinical trials on Alzheimer's patients. Two
clinical studies by Naeser et al. (2011, 2014) have reported improvements in executive
function, learning and memory after NIr treatment—delivered via an extracranial
helmet-like device using two LEDs—in a small number of patients suffering
chronic traumatic brain injury. Further, there are two human studies in healthy
individuals reporting that NIr therapy improves attention and short-term memory
(Barrett and Gonzalez-Lima, 2013) and executive functions (Blanco et al., 2015). Although these studies are promising in the sense that NIr therapy
resulted in cognitive improvements, the subjects were not Alzheimer's patients.”
“In summary, a number of
experimental studies have demonstrated that NIr therapy improves motor behavior
and provides neuroprotection in various rodent models of both Alzheimer's and
Parkinson's disease; for Parkinson's disease, these benefits have been reported
in a non-human primate model as well. However, the evidence for therapeutic
benefit at the clinical level is far sparser, prompting the need for
systematic, large-scale clinical trials of NIr therapy in Alzheimer's and
Parkinson's patients.”
“The putative NIr
protective mechanisms in the brain. (A) Direct NIr stimulation of the mitochondria of the
damaged neurons or endothelial cells. This stimulation would repair the damage
leading to neuronal protection. NIr may also stimulate neurogenesis in the
hippocampus and/or synaptogenesis in the damaged neurons (B) indirect
(remote) stimulation via circulating immune cells and/or bone marrow stem cells
leading to neuronal protection. The latter is similar to the so-called
“abscopal” effect in the treatment of cancer metastasis. We suggest that the
primary mechanism is the direct effect, of neurons and/or of endothelial cells,
while the systemic indirect effect forms a secondary supportive mechanism.”
“The phenomenon of indirect NIr-induced neuroprotection is likely to
involve the same mechanisms, at a cellular level, as those that provide
neuroprotection to damaged cells with direct NIr stimulation (i.e., stimulation
of mitochondrial function; Figure Figure2A).2A). Although the concept of indirect,
remote NIr therapy holds promise for future applications, it is not yet as
fully understood and developed as direct NIr therapy, thus our subsequent
discussion will focus primarily on direct NIr stimulation. Further, some early
results in an animal model of Parkinson's disease suggest that, although remote
NIr provides neuroprotection, this protection was not as robust as when NIr was
applied directly to the head (Stone et al., 2013; Johnstone et al., 2014b; presumably stimulating local neurons and/or endothelial cells). In other
words, neuroprotection was achieved with both local and remote NIr treatment,
but the local treatment was the more effective. As a working hypothesis, we
suggest that direct stimulation of the mitochondria and reparative mechanisms,
either in the neurons themselves or in the local endothelial cells (and/or
stimulation of neurogenesis), forms the primary mechanism of NIr-induced
neuroprotection. A more systemic (indirect) stimulation of immune and/or stem
cells may form a secondary and complementary mechanism. We suggest that
stimulation of both direct and indirect mechanisms would generate maximum
NIr-induced neuroprotection.”
“To date, there are no reports of major safety issues nor side-effects
after NIr treatment. The commercial LED panels for NIr therapy have already
received non-significant risk status by the Food and Drug Administration and
previous studies have indicated no adverse impact on brain tissue structure and
function after NIr treatment (power range from ~1 to 700 mW/cm2;
Desmet et al., 2006; Hamblin and Demidova, 2006; Ilic et al., 2006; Zivin et al., 2009; McCarthy et al., 2010; Naeser et al., 2011, 2014; Rojas and Gonzalez-Lima, 2011; Chung et al., 2012; Tata and Waynant, 2012; Quirk et al., 2012a,b; Moro et al., 2014). There is one sole account of some neuronal damage and negative
behavioral outcomes in mice, but this was evident after an exceptionally high
power intensity (750 mW/cm2; Ilic et al., 2006), approximately one hundred times higher than the dose required to elicit
a therapeutic response (e.g., < 10 mW/cm2). Hence, when taken
together, these data indicate that when NIr was applied at therapeutic doses
(and even well above these doses), its impact on body tissue was overwhelmingly
positive, and had a very large safety margin of application...” “Further, there
appears to be no longer-term side effects associated with NIr application; in a
long-term study in rats, no adverse effects were noted after daily treatment
for 12 months (McCarthy et al., 2010).”
So now we come full circle,
discussing how all the methods cited above could be even more effective when
applied, as appropriate, in concert.
For example, as we have just cited,
one possible factor in cellular deterioration in Parkinson’s and Alzheimer’s is
a shutdown in their mitochondria. The suggestions previously offered for
reactivating mitochondria for the purpose of causing apoptosis in cancerous
cells also apply when attempting to restore mitochondrial activity in failing
brain cells in Parkinson’s. To sum up, DCA has been reactivating mitochondria
in these cells so they could trigger the signal causing these otherwise
“immortal” cells to die, as has quercetin. PQQ has a similar effect on
mitochondria, especially in conjunction with COQ10 and NAC, as does NIR and the
Q1000 with its mix of FIR and visible light.
So once again, why not combine
these factors when restoring mitochondrial function, along with any other
non-toxic means of doing the same thing? And at the same time, use the
ultrasound method for removing disruptive beta-amyloids and tau proteins in Alzheimer’s
or Levy structures in Parkinson’s. You can continue to use other existing
therapies, but also consider other known, non-invasive methods for
accomplishing the same ends, such as using sensory-deprivation tanks to boost
natural dopamine levels in early-onset Parkinson’s patients.
And the synergies do not end there.
As discussed previously, every endoscope contains a fiber-optic line which can
transmit visible and infrared light, simplifying the localized concentration
of, say NIr therapy on specific cells. But if we can genetically modify an
infusion of blood to generate blue or red bio-luminescence, why not to generate
far or near infrared light? Of course, we would want to study the long-term
effects of using such infusions, but the blood circulating around the brain
might prove a relatively non-invasive means to shine the necessary frequencies
on otherwise deteriorating cells. Other alternatives might include the
permanent alteration of supportive tissues within the brain itself, though this
would require careful risk assessment as well.
Similarly,
purging the blood of pathogens on the one hand while working ones way down the
body with an ultrasound application pitched to destroy the diagnosed viral
infection could prove a useful one-two approach to avoid too many viruses
slipping past that methodical approach through our rapidly pulsing circulatory
system. Light and ultrasound could also be combined against bacterial
intruders.
And so
uniting these disparate elements forms a whole greater than its constituent parts,
a demonstration of the power of unity in diversity.
We
originally forwarded this suggestion that visible and infrared light could
combine with DCA anything else restoring mitochondrial activity as a cure to
cancer to the U.S. Federal government sometime around 10/20/16. These more
recent articles merely expand on that in light of the Vice-President’s
#CancerMoonshot, in the hope that someone may take note of any useful ideas
herein. All these suggestions are hereby placed into public domain.