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Future Imperative

What if technology were being developed that could enhance your mind or body to extraordinary or even superhuman levels -- and some of these tools were already here? Wouldn't you be curious?

Actually, some are here. But human enhancement is an incredibly broad and compartmentalized field. We’re often unaware of what’s right next door. This site reviews resources and ideas from across the field and makes it easy for readers to find exactly the information they're most interested in.

Name:

The future is coming fast, and it's no longer possible to ignore how rapidly the world is changing. As the old order changes -- or more frequently crumbles altogether -- I offer a perspective on how we can transform ourselves in turn... for the better. Nothing on this site is intended as legal, financial or medical advice. Indeed, much of what I discuss amounts to possibilities rather than certainties, in an ever-changing present and an ever-uncertain future.

Friday, December 09, 2005

Man into Supermouse -- Here I Come to Save the Day!... -- Bio

*
We've previously reported on mice created by Johns Hopkins who developed mice with muscles twice as large as normal by knocking out a gene for myostatin and letting their subjects exercise. Clinical trials of an antibody to myostatin have shown the muscles of test mice to grow 25% larger than untreated mice after five weeks or more of treatment. But now Johns Hopkins has worked with outside companies to create an even more powerful subtance that triggers a 60% increase in muscle size with just two injections.

A study in the the Proceedings of the National Academy of Sciences offers more technical details. The news release below offers an overview of the experiments.

Frankly, I think more than anything, this story indicates just how quickly things are progressing in biotech, particularly on the enhancement front. Gregory Stock, of course, would suggest that human augmentation research is mainly being driven by the tremendous push to solve other problems in biotech, from curing inherited diseases, looking for more effective vaccines or developing better tools for standard in-vitro fertilization of embryos.

In this case, it would appear that having the genetic modification is still more powerful than using even the latest agent. But researchers haven't been working on this technology very long, and already they've made this 25% to 60% jump. Sure, they'll need to test for safety, but until someone develops extra chromosomes with designer genes we can safely turn on and off, pharmaceuticals could easily be a kind of safe, middle-ground for enhancement. We may be able to flip on the attributes we want or need, and let them go when we lose interest or when we can no longer support the modifications.

This, of course, gives "ordinary humans" some recourse for keeping up with genetically modified future generations (especially those with the modified chromosomes) without having to resort to gene therapy only to balance the scales genetically. (Other options, of course, include accelerated learning, nootropics, non-invasive mindtech such as sensory deprivation tanks, self-hypnosis, virtual agents and other limited AI, nano-scale cybernetics, etc... though what you have access to will vary depending on your wealth, specialized knowledge, and of course how advanced the technology is by the time you try to utilize it.

The point, though, once again, is that augmentation tech is advancing faster than even most of its wild-eyed enthusiasts would expect. And that if we're finding ways to greatly enhance muscle mass, with or without exercise, imagine what we'll be able to do when it comes to the plasticity of the brain. Both in terms of therapy and augmentation... becoming "better than well."

So enjoy this news article. But remember, important as your strength and physique can be, we may soon be able to alter at least one organ whose modification could truly make you "more than human." Or we may just alter other people's, and leave you in a kind of permanent underclass. As F. Scott Fitzgerald said, "The rich are different from you and I." Before long, that may be literally true.

BALTIMORE, Dec. 8 (AScribe Newswire) -- The Johns Hopkins scientists who first created "mighty mice" have developed, with pharmaceutical company Wyeth and the biotechnology firm MetaMorphix, an agent that's more effective at increasing muscle mass in mice than a related potential treatment for muscular dystrophy now in clinical trials.

The new agent is a version of a cellular docking point for the muscle-limiting protein myostatin. In mice, just two weekly injections of the new agent triggered a 60 percent increase in muscle size, the researchers report in the Proceedings of the National Academy of Sciences, published online Dec. 5 and available publicly through the journal's Web site.

The researchers' original mighty mice, created by knocking out the gene that codes for myostatin, grew muscles twice as big as normal mice. An antibody against myostatin now in clinical trials caused mice to develop muscles 25 percent larger than those of untreated mice after five weeks or more of treatment.

The researchers' expectation is that blocking myostatin might help maintain critical muscle strength in people whose muscles are wasting due to diseases like muscular dystrophy or side effects from cancer treatment or AIDS.

"This new inhibitor of myostatin, known as ACVR2B, is very potent and gives very dramatic effects in the mice," says Se-Jin Lee, M.D., Ph.D., a professor of molecular biology and genetics in Johns Hopkins' Institute for Basic Biomedical Sciences. "Its effects were larger and faster than we've seen with any other agent, and they were even larger than we expected."

ACVR2B is the business end of a cellular docking point for the myostatin protein, and it probably works in part by mopping up myostatin so it can't exert its muscle-inhibiting influence. But the researchers' experiments also show that the new agent's extra potency stems from its ability to block more than just myostatin, says Lee.

"We don't know how many other muscle-limiting proteins there may be or which ones they are," says Lee, "but these experiments clearly show that myostatin is not the whole story."

The evidence for other players came from experiments with mighty mice themselves. Because these mice don't have any myostatin, any effects of injecting the new agent would come from its effects on other proteins, explains Lee. After five injections over four weeks, mighty mice injected with the new agent had muscles 24 percent larger than their counterparts that didn't get the new agent.

"In some ways this was supposed to be a control experiment," says Lee. "We weren't really expecting to see an effect, let alone an effect that sizeable."

In other experiments with normal female mice, weekly injections of the new agent provided the biggest effect on muscle growth after just two weeks at the highest dose given (50 milligrams per kilogram mouse weight). Depending on the muscle group analyzed, the treated mice's muscles were bigger than untreated mice by 39 percent (the gastrocnemius [calf] muscle) to 61 percent (the triceps).

After just one week, mice given a fifth of that highest dose had muscles 16 percent to 25 percent bigger than untreated mice, depending on the muscle group analyzed, and mice treated with one injection a week for two, three or four weeks continued to gain muscle mass.

But although the new agent seems quite promising, its advantage in potency also requires extra caution. "We don't know what else the new agent is affecting or whether those effects will turn out to be entirely beneficial," says Lee.

Lee says they also are conducting experiments with the mice now to see whether the effect lasts after injections cease and whether it helps a mouse model of muscular dystrophy retain enough muscle strength to prolong life.

The research was funded by grants from the National Institute of Child Health and Human Development and the National Cancer Institute and by funds from Wyeth Research and MetaMorphix Inc. The new agent was produced and first tested at Wyeth, and the inhibitor used in the current mouse studies was produced at MetaMorphix. All of the mouse studies described in this article and in the PNAS paper were conducted in Lee's laboratory at Johns Hopkins.

Authors on the report are Se-Jin Lee and Suzanne Sebald of Johns Hopkins; Lori Reed of Wyeth Exploratory Drug Safety, and Monique Davies, Stefan Girgenrath, Mary Goad, Kathy Tomkinson, Jill Wright and Neil Wolfman of Wyeth Discovery Research; Christopher Barker, Gregory Ehrmantraut, James Holmstrom and Betty Trowell of MetaMorphix Canada; Barry Gertz, Man-Shiow Jiang, Li-fang Liang, Edwin Quattlebaum and Ronald Stotish of MetaMorphix, Beltsville, Md.; Martin Matzuk of Baylor College of Medicine; and En Li of Harvard Medical School.

Myostatin was licensed by The Johns Hopkins University to MetaMorphix and sublicensed to Wyeth. Lee is entitled to a share of sales royalty received by The Johns Hopkins University from sales of this factor. The Johns Hopkins University and Lee also own MetaMorphix stock, which is subject to certain restrictions under university policy. Lee is a paid consultant to MetaMorphix.

The terms of these arrangements are being managed by the university in
accordance with its conflict of interest policies.
- - - -

CONTACT: Joanna Downer, Johns Hopkins Medicine Office of Corporate
Communications, 410-614-5105, jdowner1@jhmi.edu
ON THE WEB: http://www.pnas.org/cgi/content/abstract/0505996102v1

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Anonymous Anonymous said...

Your subconscious mind is a powerful force. It can be an un-defeatable ally or a dangerous foe! It is a powerful force of nature that can be harnessed and made to work for us or it can be a wild beast that runs riot with our lives.
How powerful is 'powerful'?
Take the first Atomic Bomb - it could lay waste to an entire city in seconds. Or the gravitational pull of the Sun which stops our tiny planet from hurtling into space. Imagine the power of a black hole - that region of spacetime from which nothing can escape not even light travelling at 186 thousand miles a second. The Universe is full of powerful forces. Yet, all these wondrous things pale into insignificance when compared to the power of the subconscious mind.
The subconscious part of your mind is that part which regulates your heartbeat, lungs, digestive system and everything else in your body. It directs the inner workings of your body and such things as (what biologists call) 'machines' - tiny living cells that are composed of motors, drive-shafts and propellers - seriously!!! There is mounting evidence that the cells in our bodies have memory and that our very DNA is coded with memories of our ancestors. As well as having full control of all these functions and more your subconscious also retains all the thoughts, experiences and emotions you have ever felt. It regulates the most complicated mechanism in the unknown Universe - your body - and it can calculate the trajectory of multiple moving objects while supplying you with the words necessary to debate an issue while controlling a complex task of activities such as driving a car!
These tasks alone show how powerful the subconscious mind is. But it is much more powerful than that!
The truth is: No-one knows the limits of the subconscious mind's power!
Tell yourself that you will wake up at 6 a.m. and chances are you will awake. Go to a crowed party and through a mass of voices you will hear someone at the other side of the room mention your name! Set a problem aside and miraculously, out of nowhere, the answer comes while you are involved in another task. It recreates situations in your life that correspond to your beliefs. Time and time again you find yourself in the same situations, with similar partners, in almost identical jobs. Like a wheel your subconscious mind creates situations that bring your life back to the same spot.
Likewise it can totally transform your life - even overnight! It can bring you new situations, life experiences, luxuries and even people.
However, it is like a na�ve child or a better analogy is that of a computer. It believes everything that you tell it. Your conscious mind is the gatekeeper. Anything you think with complete faith is immediately past to the subconscious mind - which it then takes as literal fact. There will be no arguments because it has no discriminating capabilities.
Although your subconscious mind is more powerful than you can possibly imagine it is a mere servant. It is at your disposal. YOU are in charge. It acts just like a computer and like every computer it needs software to run. So if you do not program it then someone else will! You are constantly being bombarded with software programs for the mind every minute of everyday. Buy this product and you will look slim, drive this car and you will seem sexy, drink this potion and you will feel more vibrant about life. You are told what to buy and when to buy it, when you are too young to do a thing and when you are too old. You are told what is possible and what is not. Snap out of it!
Take back your control over mind and body. You were born with the most powerful computer system known to man - a bio-computer that regulates a sophisticated, highly flexible, changeable, self repairing vehicle. You are amazing, a true miracle. If you bought a new top of the range diesel Mercedes would you let Joe or Sue down the road fill it up with petrol?
Begin to think for yourself. Who told you that you could not achieve your dreams? Do you believe it? Who told you that you were too fat, too skinny, too stupid, too smart, too young or too old?
Does it matter?
No! Because you are and always have been in total control. Change your thinking and you will change your subconscious beliefs. Change your subconscious beliefs and you will change your life. self-hypnosis

May 31, 2006 6:39 PM  
Anonymous Anonymous said...

Many people try to achieve goals. Most fail. Some strive, work hard and plan for all the details yet they achieve little or nothing at all. Others strive, work hard, plan and achieve huge success. Yet there are a few individuals who do little else than take small steps and seem to achieve a great deal with what seems like effortlessness. What is the difference between these people and which one would you like to be?
Most members of the human race fall into two categories - those who live in the past and those who live in the future. Most live in the past. Many of these are the people who achieve very little in their lives and are so fearful of the future that they dare not strike out to get anything. They are the under-achievers who hang onto bad episodes in their lives and either relive them time and again or look at new situations as similar potentialities. They say things like "all men are deceivers" or "all women are interested in is money" or "I can't do it. I tried before and it didn't work so why bother!". Due to bad experiences in the past they believe that all future events will turn out the same way if they dare to go after what they want.
The other type of person lives in the future. This type tends to create more of the things they want in life. They have a vision of where they want to go and exactly how they are going to get there. They work diligently at making concrete plans and they pursue those plans with a persistent ferocious appetite for success. These people are the high achievers - The Richard Branson and Bill Gates of the world. These people have much to teach us about setting and achieving goals.
However, there is a third type of person who almost goes unnoticed. They are the person who takes life in its stride and yet achieve most of what they want. I am sure you know of such a person in your life that just seems to saunter through life and yet they always come out on top. Or a person who you hear of that has decided to open a shop. You meet them a few months later and they have three shops all doing well! So what makes these people so successful and if they aren't living in the past and aren't living in the future where are they living?
I suppose you guessed it! Whether they are consciously aware of it or not they are living in the present. It is in the 'living' present that we have our greatest power. Everything happens in the present. You live your entire life there - even if your mind does not!
By becoming more aware of the present and by 'accepting' it as it is we are much more in control of our emotions and focus. When we live in the past we are fearful of making bad choices and/or getting hurt. We do not wish to recreate the past again! When we live in the future we can also be fearful of what might happen. But even if your future vision is full of power and worthy of working towards many people can, and often do, get stuck there. By constantly reaching for bigger and better goals they fail to enjoy what they have in the moment.
If you wish to start living a life that is almost effortless begin first by living in the present. Accept your situation the way it is and then you can enjoy what you have. Your focus changes from a memory of what was or a vision of what might be to a realization of what is. You become much more empowered to then see the beauty of life and also look at where you wish to make changes. But to make changes you must first accept the situation as it is. Trying to escape from your present only increases your focus on your problems by creating resistance to what is. Accept your life as it is now. Make no judgement, just accept it and then you will be free of doubt, worry, pain and fear. For you only experience these things when you live outside the 'moment'. personal-development.info

June 05, 2006 4:48 PM  
Anonymous Hypnotize said...

Visualization is a tool that has been used for thousands of years by initiates of all the metaphysical schools. Today, it is incorporated into top athlete's daily routines and is used in business affairs frequently. It's use is wide-spread among highly successful people, either consciously or unconsciously, aware of its create power. So if it has stood the test of time and is still being used by high achievers we must come to the conclusion that it works! But has it ever worked for you?

If you answered 'yes' to the above question then you know how powerful this technique can be. If, on the other hand, you gave the more likely answer 'no' then take heart for I am about to reveal to you a sure fire way of reaching your objectives through this mostly misunderstood art.

The trouble with visualization is simple - its in its name!

When studying and contemplating the art of visualization most people have the impression that they must create visual images and make them real or life-like. Many people, in fact the majority, find this almost impossible to do. Even if they can formulate a solid picture of their objective they find it extremely difficult to sustain the image for any length of time. Either the image fades, changes or other intruding thoughts intervene.

This type of visualization is almost impossible to sustain and luckily it is not at all necessary. Why? Because it is in the subconscious mind that your visualization needs to be placed and there is good news. The subconscious mind does not know the difference between an imaginary event and a real one. Your visual image only needs to be a strong visually as any other imagined event. However, that is only half the story.

If all you had to do was just imagine stuff and your world automatically changed to reflect your imaginings this world would be full of chaos (not to mention all those creepy crawly bug-eyed monsters!). Therefore, there are a few more steps to complete before the visualization is passed to the subconscious for manifestation.

Let's try a little experiment. Remember a scene from your past that has a lot of good feelings around it. Any good memory will do, like the first time you heard the words "I love you" from your partner, an amazingly spectacular sunset, a great holiday event or your last birthday. Pick one and remember it. How clear is the image? Can you remember any sounds? What way did you feel? Is there any sense of touch, taste or smell? Identify how your memory works. Is it mostly visual, auditory, kinaesthetic or of a feeling nature?

Now we are going to create an imagined event in our lives that has the same strength and potency as that image. So relax and let's go.

Imagine something that you do everyday, something that you did yesterday, today and will do tomorrow. Let us take the example of waking up tomorrow morning. Don't try to add or take anything away, just think about it and analyse the scene. Is it dark or light? Are you lying next to someone in bed? Do you still feel tired? Has the alarm clock sounded? Are you irritable that you have to get up or full of joy at the dawn of a new day?

You will find that the imagined event is very similar to the memory with probably one key difference - your point of perspective. Is the memory behind you and the future event in front of you? Is one to the left and one to the right? Maybe they are both in front of you or the future seems to move in a clockwise direction. Whatever the perspective the thing to notice is that they are very similar in appearance.

Now imagine doing your future event a week from now, then a month from now, then six months from now. Where are those images placed? Are they moving further away, going clockwise, from left to right? This is your time-line and using it is important in visualization as you will see later.

Ok, let's imagine something that is very unlikely to happen and see where it differs from the last image.

Imagine you are sitting somewhere familiar which is extremely comfortable and relaxing to you. Now imagine that a person you know well comes up to where you are and says "hello". Imagine them telling you that they want to show you a new trick. All of a sudden they have three juggling balls. They throw them in the air and begin to juggle with ease. Then they begin to whistle one of your favourite tunes. You suddenly realize that there is a strong smell of flowers in the room and notice a vase of them just behind the juggler. Imagine laughing loudly at the scene and feeling joyful at the experience. Then the person juggling leans forward stands on leg and puts the other leg outstretched behind them. All the while still juggling and whistling. Then they begin to hop on their leg as a small bird flies over to perch on their head. Once you have the imagined event and stayed with it a few moments just let it fade.

Ok open your eyes. What was the difference between the two images? Can you spot any? Did you use more, less or roughly the same senses in your fantasy event as you did in the future one? Did you see them from different angles? Was the picture bigger in one than the other? Was the sound clearer, the feelings more acute or the smell stronger? Take some time and go back to each scene in your mind. How does the future event differ from the fantasy one? Are you looking at both from a different vantage point? Do you see yourself in the image of one but not the other? Analyse the scenes and see where they differ.

Have you identified how the future event differs from the fantasy one? If you have then its time to make visualization work for you! Take a goal that you have been working on or would like to achieve. Nothing too far-fetched at this point please! Pick something that is possible but at the moment seems a little impractical. Once you have it form a mental image of what it would be like to have, be or do that thing or be in that experience. Remember to form it the same way you do a memory. Give it the same strength visually, in sound, feeling, taste and touch - use your mind in its natural state. All you have to do is imagine the scene.

Ok how does it differ from the scene of waking in the morning? Can you identify the differences in perspective, sound, taste, touch, feelings and what you hear?

Now there will be one other key thing that differs in the images- it is very simple but often overlooked. You know that the future event is going to happen! This is reflected in the way we experience the image. So what we are going to do is fool your subconscious mind into thinking your goal is definitely going to happen by manipulating your goal image!

Once you know what the differences are in each image begin to change the goal image so that it is seen the same way as the future event in your imagination. Place the visualized scene in exactly the same position with the same perspective as your future event.

Place it in the correct position on your time-line. You may already begin to feel that the goal is more possible. Visualise in this way everyday and you will condition your subconscious mind to manifest the experiences necessary to make your goal attainment certain.

One more thing to remember: During the day think about your goal often. This reinforces the visualization and will begin to dispel doubt from your mind. subliminal messages

June 18, 2006 9:53 PM  
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We've previously reported on mice created by Johns Hopkins who developed mice with muscles twice as large as normal by knocking out a gene for myostatin and letting their subjects exercise.

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